InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spred2

Summary

InnateDB Protein

IDBP-152432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spred2

Protein Name

sprouty-related, EVH1 domain containing 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090987

InnateDB Gene

IDBG-152428 (Spred2)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. {ECO:0000269PubMed:11493923}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:11493923}. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in lung, liver and testis. In testis, it is specially found in mature spermatids projecting into the lumen of the seminiferous. Strongly expressed in glandular epithelia. Also expressed in embryonic tissues such as heart, lung, liver and brain. {ECO:0000269PubMed:11493923, ECO:0000269PubMed:15580519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311	regulation of protein deacetylation