Version 5.4
Mus musculus Protein: Serpini1
Summary
InnateDB Protein IDBP-152515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpini1
Protein Name serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms AI837402; Ns; PI-12; PI12; Spi17;
Species Mus musculus
Ensembl Protein ENSMUSP00000029423
InnateDB Gene IDBG-152513 (Serpini1)
Protein Structure
UniProt Annotation
Function Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030155 regulation of cell adhesion
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1194506
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35684
PhosphoSite PhosphoSite-
TrEMBL E0CYW0
UniProt Splice Variant
Entrez Gene 20713
UniGene Mm.41560
RefSeq NP_033276
MGI ID 1JJO
MGI Symbol Serpini1
OMIM
CCDS CCDS17415
HPRD
IMGT
EMBL AC140430 AJ001700 AK032152 AK051756 BC006776
GenPept AAH06776 BAC27727 BAC34756 CAA04939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca