InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo1b

Summary

InnateDB Protein

IDBP-152518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo1b

Protein Name

myosin IB

Synonyms

AA406997; MIH-L; MMIa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040447

InnateDB Gene

IDBG-152516 (Myo1b)

Protein Structure

UniProt Annotation

Function

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Subcellular Localization

Disease Associations

Tissue Specificity

Prominent expression is seen in the brain, lung and liver. It is also expressed in the heart and testis. A high level expression is seen in virtually all neurons (but not glia) in the postnatal and adult mouse brain and in neuroblasts of the cerebellar external granular layer.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0008152	metabolic process
GO:0030048	actin filament-based movement
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016459	myosin complex
GO:0030175	filopodium
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:107752

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF06017

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt