InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actr2

Summary

InnateDB Protein

IDBP-152545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actr2

Protein Name

ARP2 actin-related protein 2 homolog (yeast)

Synonyms

4921510D23Rik; AA409782; Arp2; D6Ertd746e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000137

InnateDB Gene

IDBG-152543 (Actr2)

Protein Structure

UniProt Annotation

Function

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding
GO:0005524	ATP binding

Biological Process

GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0016482	cytoplasmic transport
GO:0030036	actin cytoskeleton organization
GO:0033206	cytokinesis after meiosis
GO:0051321	meiotic cell cycle
GO:0051653	spindle localization