InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgdr

Summary

InnateDB Protein

IDBP-152640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgdr

Protein Name

prostaglandin D receptor

Synonyms

DP; PGD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093653

InnateDB Gene

IDBG-152638 (Ptgdr)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030238	male sex determination
GO:0030431	sleep
GO:0046085	adenosine metabolic process
GO:0071799	cellular response to prostaglandin D stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:102966

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000376 Prostaglandin D receptor
IPR001105 Thromboxane receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00854
PR00429
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70263