Version 5.4
Mus musculus Protein: Fkbp15
Summary
InnateDB Protein IDBP-152710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp15
Protein Name FK506 binding protein 15
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081575
InnateDB Gene IDBG-152708 (Fkbp15)
Protein Structure
UniProt Annotation
Function Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase. {ECO:0000250, ECO:0000269PubMed:16756961}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16756961}. Cell projection, axon {ECO:0000269PubMed:16756961}. Early endosome {ECO:0000269PubMed:16756961}. Note=Present in axons and neuronal growth cones.
Disease Associations
Tissue Specificity Expressed in brain, with highest levels in the granular cell layer of cerebellum and in the granule cell layer of dentate gyrus. {ECO:0000269PubMed:16756961}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006457 protein folding
GO:0006897 endocytosis
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005769 early endosome
GO:0005884 actin filament
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
Protein Structure and Domains
PDB ID MGI:2444782
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
PFAM PF00254
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9Q6
PhosphoSite PhosphoSite-Q6P9Q6
TrEMBL B2RQ18
UniProt Splice Variant
Entrez Gene 338355
UniGene
RefSeq NP_001038993
MGI ID
MGI Symbol Fkbp15
OMIM
CCDS CCDS51201
HPRD
IMGT
EMBL AK122343 AK161705 AL683829 AL732548 BC060651 BC137706
GenPept AAH60651 AAI37707 BAC65625 BAE36541 CAI25942 CAI26145

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca