Version 5.4
Mus musculus Protein: Fbxo38
Summary
InnateDB Protein IDBP-152750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo38
Protein Name F-box protein 38
Synonyms 6030410I24Rik; AU044865; AW214031; Moka; SP329;
Species Mus musculus
Ensembl Protein ENSMUSP00000047541
InnateDB Gene IDBG-152748 (Fbxo38)
Protein Structure
UniProt Annotation
Function Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination. {ECO:0000269PubMed:14729953}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14729953}. Nucleus {ECO:0000269PubMed:14729953}.
Disease Associations
Tissue Specificity Expressed at high levels in embryo (developing brain, spinal chord, branchial arms and limbs). Widely expressed at low levels in adult tissues, with highest expression in testis. Expressed in postmeiotic spermatids. {ECO:0000269PubMed:14729953}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2444639
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMI0
PhosphoSite PhosphoSite-Q8BMI0
TrEMBL Q8R576
UniProt Splice Variant
Entrez Gene 107035
UniGene Mm.394903
RefSeq NP_598897
MGI ID
MGI Symbol Fbxo38
OMIM
CCDS CCDS37841
HPRD
IMGT
EMBL AK031096 AK031347 AK089046 AY267463 BC023176 BC056348
GenPept AAH23176 AAH56348 AAP31028 BAC27250 BAC27358 BAC40718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca