InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grid2

Summary

InnateDB Protein

IDBP-152792.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grid2

Protein Name

glutamate receptor, ionotropic, delta 2

Synonyms

B230104L07Rik; cpr; GluD2; GluRdelta2; ho; Lc; Lc; MMS10-AC; Ms10ac; nmf408; tpr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093536

InnateDB Gene

IDBG-152790 (Grid2)

Protein Structure

UniProt Annotation

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Note=Defects in Grid2 are the cause of the Lurcher phenotype. Heterozygous animals display a characteristic swaying of the hind quarters and jerky up and down movements following cerebellar Purkinje cell degeneration during postnatal development. Homozygous animals die shortly after birth because of a massive loss of midbrain and hindbrain neurons during late embryogenesis.

Tissue Specificity

Expressed selectively in cerebellar Purkinje cells where it is localized in dendritic spines. {ECO:0000269PubMed:15207857, ECO:0000269PubMed:7506541}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006810	transport
GO:0007157	heterophilic cell-cell adhesion
GO:0010975	regulation of neuron projection development
GO:0021707	cerebellar granule cell differentiation
GO:0034220	ion transmembrane transport
GO:0034613	cellular protein localization
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0043523	regulation of neuron apoptotic process
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060134	prepulse inhibition

Cellular Component

GO:0005886	plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0016020	membrane
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95813

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt