Version 5.4
Mus musculus Protein: Spink10
Summary
InnateDB Protein IDBP-152911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spink10
Protein Name serine peptidase inhibitor, Kazal type 10
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062976
InnateDB Gene IDBG-152909 (Spink10)
Protein Structure
UniProt Annotation
Function Probable serine protease inhibitor.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in epydiymis, in the cauda and corpus. Also expressed in brain. {ECO:0000269PubMed:16930550}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3584533
InterPro IPR001239 Proteinase inhibitor I1, Kazal metazoa
IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS PR00290
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CAC8
PhosphoSite PhosphoSite-
TrEMBL E0CXG7
UniProt Splice Variant
Entrez Gene 328971
UniGene Mm.312675
RefSeq NP_808497
MGI ID
MGI Symbol Spink10
OMIM
CCDS CCDS29293
HPRD
IMGT
EMBL AC124383 AC165083 AK039062 BC125360 BC125362 CH466528 DQ437330
GenPept AAI25361 AAI25363 ABD93325 BAC30226 EDL09733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca