InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Narfl

Summary

InnateDB Protein

IDBP-152950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Narfl

Protein Name

nuclear prelamin A recognition factor-like

Synonyms

9030612I22Rik; AI504405; PRN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002350

InnateDB Gene

IDBG-152948 (Narfl)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001666	response to hypoxia
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0016226	iron-sulfur cluster assembly
GO:0032364	oxygen homeostasis