InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sptlc1

Summary

InnateDB Protein

IDBP-153037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sptlc1

Protein Name

serine palmitoyltransferase, long chain base subunit 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021920

InnateDB Gene

IDBG-153035 (Sptlc1)

Protein Structure

UniProt Annotation

Function

Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:1317856}; Single-pass membrane protein {ECO:0000269PubMed:1317856}.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues. Highest expression in brain, kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004758	serine C-palmitoyltransferase activity
GO:0005515	protein binding
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006686	sphingomyelin biosynthetic process
GO:0009058	biosynthetic process
GO:0046511	sphinganine biosynthetic process
GO:0046512	sphingosine biosynthetic process
GO:0046513	ceramide biosynthetic process