Version 5.4
Mus musculus Protein: Apcdd1
Summary
InnateDB Protein IDBP-153052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apcdd1
Protein Name adenomatosis polyposis coli down-regulated 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000094302
InnateDB Gene IDBG-153050 (Apcdd1)
Protein Structure
UniProt Annotation
Function Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017147 Wnt-protein binding
Biological Process
GO:0001942 hair follicle development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0043615 astrocyte cell migration
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:3513977
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U128
PhosphoSite PhosphoSite-Q3U128
TrEMBL
UniProt Splice Variant
Entrez Gene 494504
UniGene
RefSeq NP_573500
MGI ID
MGI Symbol Apcdd1
OMIM
CCDS CCDS37843
HPRD
IMGT
EMBL AK156319 AK172004 BC141269 BC141270
GenPept AAI41270 AAI41271 BAE33672 BAE42770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca