InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmc6

Summary

InnateDB Protein

IDBP-153113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmc6

Protein Name

proteasome (prosome, macropain) 26S subunit, ATPase, 6

Synonyms

2300001E01Rik; AI451058;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022380

InnateDB Gene

IDBG-153111 (Psmc6)

Protein Structure

UniProt Annotation

Function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030163	protein catabolic process
GO:0090261	positive regulation of inclusion body assembly

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016234	inclusion body
GO:0022624	proteasome accessory complex
GO:0031597	cytosolic proteasome complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914339

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005937 26S proteasome subunit P45
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62334