InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccdc78

Summary

InnateDB Protein

IDBP-153128.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccdc78

Protein Name

coiled-coil domain containing 78

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093155

InnateDB Gene

IDBG-153126 (Ccdc78)

Protein Structure

UniProt Annotation

Function

Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0003009	skeletal muscle contraction
GO:0030030	cell projection organization
GO:0098535	de novo centriole assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005814	centriole
GO:0016529	sarcoplasmic reticulum
GO:0042383	sarcolemma
GO:0048471	perinuclear region of cytoplasm
GO:0098536	deuterosome