InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msx2

Summary

InnateDB Protein

IDBP-153224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msx2

Protein Name

homeobox, msh-like 2

Synonyms

BB122635; Hox-8; Hox8; Hox8.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021922

InnateDB Gene

IDBG-153222 (Msx2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269PubMed:15383550, ECO:0000269PubMed:1677742}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in mesenchymal tissue in the developing spinal cord and limbs.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000989	transcription factor binding transcription factor activity
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0002063	chondrocyte development
GO:0002076	osteoblast development
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003416	endochondral bone growth
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032792	negative regulation of CREB transcription factor activity
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0035313	wound healing, spreading of epidermal cells
GO:0035880	embryonic nail plate morphogenesis
GO:0042060	wound healing
GO:0042476	odontogenesis
GO:0042640	anagen
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048863	stem cell differentiation
GO:0051216	cartilage development
GO:0051795	positive regulation of catagen
GO:0060346	bone trabecula formation
GO:0060349	bone morphogenesis
GO:0060364	frontal suture morphogenesis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0061180	mammary gland epithelium development
GO:0061312	BMP signaling pathway involved in heart development
GO:0070166	enamel mineralization
GO:0071363	cellular response to growth factor stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0090427	activation of meiosis
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001055	positive regulation of mesenchymal cell apoptotic process