InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EXTL3

Summary

InnateDB Protein

IDBP-15323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXTL3

Protein Name

exostoses (multiple)-like 3

Synonyms

BOTV; EXTL1L; EXTR1; REGR; RPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000220562

InnateDB Gene

IDBG-15321 (EXTL3)

Protein Structure

UniProt Annotation

Function

Probable glycosyltransferase (By similarity). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. {ECO:0000250, ECO:0000269PubMed:22727489}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10639137}; Single-pass type II membrane protein {ECO:0000269PubMed:10639137}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed in keratinocytes. {ECO:0000269PubMed:22727489}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001888	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030307	positive regulation of cell growth
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane