InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfxn1

Summary

InnateDB Protein

IDBP-153307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfxn1

Protein Name

sideroflexin 1

Synonyms

2810002O05Rik; A930015P12Rik; f;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021930

InnateDB Gene

IDBG-153305 (Sfxn1)

Protein Structure

UniProt Annotation

Function

Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

Subcellular Localization

Mitochondrion membrane; Multi-pass membrane protein.

Disease Associations

Note=Defects in Sfxn1 are the cause of a transitory hypochromic, microcytic anemia characterized by a large number of siderocytes containing non-heme iron granules. The anemia begins at 12 dpc, is most intense at 15 dpc and is still severe at birth, but disappears by 2 weeks of age. Mutant adults are no longer anemic, but they have an impaired response to hemopoietic stress. Most homozygotes also have flexed tails and a belly spot. {ECO:0000269PubMed:11274051}.

Tissue Specificity

Widely expressed, with highest expression in kidney and liver. {ECO:0000269PubMed:11274051}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006826	iron ion transport
GO:0030218	erythrocyte differentiation
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport