InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mfi2

Summary

InnateDB Protein

IDBP-153322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfi2

Protein Name

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

Synonyms

CD228; MTf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023464

InnateDB Gene

IDBG-153320 (Mfi2)

Protein Structure

UniProt Annotation

Function

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0010756	positive regulation of plasminogen activation
GO:0090091	positive regulation of extracellular matrix disassembly
GO:0097286	iron ion import
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031225	anchored component of membrane
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome