Version 5.4
Mus musculus Protein: Setx
Summary
InnateDB Protein IDBP-153369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setx
Protein Name senataxin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051492
InnateDB Gene IDBG-153367 (Setx)
Protein Structure
UniProt Annotation
Function Probable helicase involved in RNA maturation. Required for the 3' transcriptional termination of PER1 and CRY2, plays an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress. {ECO:0000269PubMed:22767893}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:16644229}. Nucleus, nucleolus {ECO:0000269PubMed:16644229}. Cytoplasm {ECO:0000269PubMed:16644229}. Note=Most abundant in the nucleus (By similarity). Detected in granules (By similarity). Colocalized in cycling cells with FBL in the nucleolus (By similarity). May be detected in the nucleolus only in cycling cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in cerebellum, hippocampus, olfactory bulb, Bergmann glial fibers, stellate cells and Purkinje cells. Expressed in the epithelial cells of the lens but not in mature lens fiber cells. Expressed in the retina (highly expressed in inner and outer segments of photoreceptors and outer plexiform layer cells but weakly expressed in the inner plexiform and ganglion cell layers). Expressed in the kidney. {ECO:0000269PubMed:16644229}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006302 double-strand break repair
GO:0006369 termination of RNA polymerase II transcription
GO:0007623 circadian rhythm
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2443480
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AKX3
PhosphoSite PhosphoSite-A2AKX3
TrEMBL
UniProt Splice Variant
Entrez Gene 269254
UniGene Mm.472481
RefSeq NP_932150
MGI ID
MGI Symbol Setx
OMIM
CCDS CCDS38090
HPRD
IMGT
EMBL AK044730 AK048354 AK077911 AK129177 AL772379 AL845267 BC046382 BC058109 BC079604 BK001523
GenPept AAH46382 AAH58109 AAH79604 BAC32054 BAC33309 BAC37058 BAC97987 CAM16246 CAM23971 CAM23973 DAA01946

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca