InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actn1

Summary

InnateDB Protein

IDBP-153382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actn1

Protein Name

actinin, alpha 1

Synonyms

3110023F10Rik; Actn1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021554

InnateDB Gene

IDBG-153380 (Actn1)

Protein Structure

UniProt Annotation

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0019904	protein domain specific binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0051015	actin filament binding

Biological Process

GO:0030865	cortical cytoskeleton organization
GO:0048041	focal adhesion assembly
GO:0051017	actin filament bundle assembly
GO:0051271	negative regulation of cellular component movement
GO:0051764	actin crosslink formation

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0030018	Z disc
GO:0030141	secretory granule
GO:0030863	cortical cytoskeleton
GO:0030864	cortical actin cytoskeleton
GO:0032127	dense core granule membrane
GO:0042995	cell projection
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2137706

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM