InnateDB Protein
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IDBP-153414.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ufsp2
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Protein Name
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UFM1-specific peptidase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034051
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InnateDB Gene
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IDBG-153412 (Ufsp2)
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Protein Structure
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Function |
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. {ECO:0000269PubMed:17182609, ECO:0000269PubMed:21228277}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:21228277}. Endoplasmic reticulum {ECO:0000269PubMed:21228277}. Nucleus {ECO:0000269PubMed:21228277}.
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Disease Associations |
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Tissue Specificity |
Expressed at high level in brain, kidney, stomach, skeletal muscle and testis. {ECO:0000269PubMed:17182609}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016790
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thiolester hydrolase activity
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GO:0019783
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small conjugating protein-specific protease activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913679
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InterPro |
IPR012462
Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2
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PFAM |
PF07910
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99K23
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PhosphoSite |
PhosphoSite-Q99K23
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
192169
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UniGene |
Mm.210882
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RefSeq |
NP_619609
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MGI ID |
3OQC
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MGI Symbol |
Ufsp2
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OMIM |
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CCDS |
CCDS22284
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HPRD |
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IMGT |
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EMBL |
AK075795
AK078309
BC005503
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GenPept |
AAH05503
BAC35964
BAC37214
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