Version 5.4
Mus musculus Protein: Senp5
Summary
InnateDB Protein IDBP-153499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Senp5
Protein Name SUMO/sentrin specific peptidase 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023457
InnateDB Gene IDBG-153497 (Senp5)
Protein Structure
UniProt Annotation
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
GO:0008150 biological_process
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:2443596
InterPro IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1
PFAM PF02902
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NXL6
PhosphoSite PhosphoSite-Q6NXL6
TrEMBL
UniProt Splice Variant
Entrez Gene 320213
UniGene Mm.152890
RefSeq NP_796077
MGI ID
MGI Symbol Senp5
OMIM
CCDS CCDS28111
HPRD
IMGT
EMBL AK043171 AY522918 BC067014 BC080830
GenPept AAH67014 AAH80830 AAT01901 BAC31483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca