InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clmp

Summary

InnateDB Protein

IDBP-153521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clmp

Protein Name

RIKEN cDNA 9030425E11 gene

Synonyms

9030425E11Rik; ACAM; ASP5; AW557819;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034522

InnateDB Gene

IDBG-153519 (Clmp)

Protein Structure

UniProt Annotation

Function

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:14573622}. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in the heart and brain, at intermediate levels in the lung, skeletal muscle, kidney and testis and at low levels in the liver and spleen. {ECO:0000269PubMed:14573622, ECO:0000269PubMed:15563274}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0048565

digestive tract development

Cellular Component

GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1918816

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013270 CD47 immunoglobulin-like

PFAM

PF07679
PF07686
PF08204

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R373