Version 5.4
Mus musculus Protein: Ntng2
Summary
InnateDB Protein IDBP-153618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ntng2
Protein Name netrin G2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035468
InnateDB Gene IDBG-153616 (Ntng2)
Protein Structure
UniProt Annotation
Function Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. {ECO:0000269PubMed:11804778}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11804778}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:11804778}; Extracellular side {ECO:0000269PubMed:11804778}.
Disease Associations
Tissue Specificity Expression is restricted primarily to neurons of the CNS, particularly in the cerebral cortex, habenular nucleus and superior colliculus. Low levels in lung, kidney, heart and spleen. {ECO:0000269PubMed:11804778, ECO:0000269PubMed:11906208}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0030424 axon
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID MGI:2159341
InterPro IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR013111 EGF-like domain, extracellular
PFAM PF00008
PF00053
PF00055
PF07974
PRINTS
PIRSF
SMART SM00181
SM00180
SM00136
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R4F1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 171171
UniGene Mm.448826
RefSeq NP_598008
MGI ID
MGI Symbol Ntng2
OMIM
CCDS CCDS15852
HPRD
IMGT
EMBL AB052336 AB052337 AB052338 AF475079 AF475080 AL772379 CH466542
GenPept AAL84788 AAL84789 BAB71994 BAB71995 BAB71996 CAM16243 EDL08409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca