InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srpk3

Summary

InnateDB Protein

IDBP-153643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srpk3

Protein Name

serine/arginine-rich protein specific kinase 3

Synonyms

Mssk1; Stk23;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002081

InnateDB Gene

IDBG-153641 (Srpk3)

Protein Structure

UniProt Annotation

Function

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development. {ECO:0000269PubMed:16140986}.

Subcellular Localization

Disease Associations

Tissue Specificity

Exclusively expressed in skeletal and heart muscle. {ECO:0000269PubMed:16140986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007519	skeletal muscle tissue development
GO:0030154	cell differentiation
GO:0060537	muscle tissue development

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1891338

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt