InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs3

Summary

InnateDB Protein

IDBP-153656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs3

Protein Name

regulator of G-protein signaling 3

Synonyms

4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3; RGS3S;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081569

InnateDB Gene

IDBG-153650 (Rgs3)

Protein Structure

UniProt Annotation

Function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269PubMed:11301003, ECO:0000269PubMed:12210723}.

Subcellular Localization

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=The long isoforms are cytoplasmic.Isoform 3: Nucleus. Note=Isoform 3 and probably also isoform 4 are nuclear.Isoform 4: Nucleus. Note=Isoform 3 and probably also isoform 4 are nuclear.

Disease Associations

Tissue Specificity

Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. {ECO:0000269PubMed:11034339}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity