InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Otx1

Summary

InnateDB Protein

IDBP-153663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Otx1

Protein Name

orthodenticle homolog 1 (Drosophila)

Synonyms

A730044F23Rik; jv;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006071

InnateDB Gene

IDBG-153661 (Otx1)

Protein Structure

UniProt Annotation

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0022037	metencephalon development
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0042472	inner ear morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048852	diencephalon morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:97450

InterPro

IPR001356 Homeobox domain
IPR003025 Transcription factor Otx
IPR003026 Transcription factor Otx1
IPR009057 Homeodomain-like
IPR013851 Transcription factor Otx, C-terminal

PFAM

PF00046
PF03529

PRINTS

PR01255
PR01256

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt