InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CABLES1

Summary

InnateDB Protein

IDBP-1537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CABLES1

Protein Name

Cdk5 and Abl enzyme substrate 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256925

InnateDB Gene

IDBG-1535 (CABLES1)

Protein Structure

UniProt Annotation

Function

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269PubMed:11585773, ECO:0000269PubMed:14729625}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

Biological Process

GO:0007049	cell cycle
GO:0007399	nervous system development
GO:0007596	blood coagulation
GO:0045859	regulation of protein kinase activity
GO:0051301	cell division
GO:0051302	regulation of cell division
GO:0051726	regulation of cell cycle