Version 5.4
Mus musculus Protein: Smc5
Summary
InnateDB Protein IDBP-153753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smc5
Protein Name structural maintenance of chromosomes 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000084837
InnateDB Gene IDBG-153751 (Smc5)
Protein Structure
UniProt Annotation
Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11408570, ECO:0000269PubMed:20339383}. Chromosome {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Note=Associates with chromatin.
Disease Associations
Tissue Specificity Expressed in testis but not ovary. {ECO:0000269PubMed:20339383}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0090398 cellular senescence
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0016605 PML body
GO:0030054 cell junction
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID MGI:2385088
InterPro IPR003395 RecF/RecN/SMC, N-terminal
IPR015988 STAT transcription factor, coiled coil
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02463
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CG46
PhosphoSite PhosphoSite-Q8CG46
TrEMBL
UniProt Splice Variant
Entrez Gene 226026
UniGene
RefSeq NP_722503
MGI ID
MGI Symbol Smc5
OMIM
CCDS CCDS37936
HPRD
IMGT
EMBL AJ534941 AK122321 BC007174 BC038345
GenPept AAH07174 AAH38345 BAC65603 CAD59184

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca