InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn3

Summary

InnateDB Protein

IDBP-153769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn3

Protein Name

cyclin-dependent kinase inhibitor 3

Synonyms

2410006H10Rik; KAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070575

InnateDB Gene

IDBG-153767 (Cdkn3)

Protein Structure

UniProt Annotation

Function

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). {ECO:0000250UniProtKB:Q16667}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250UniProtKB:Q16667}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007050	cell cycle arrest
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1919641

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008425 Cyclin-dependent kinase inhibitor 3
IPR022778 CDKN3 domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF05706

PRINTS

PR00700

PIRSF

PIRSF037322

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References