InnateDB Protein
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IDBP-153780.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Med27
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Protein Name
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mediator complex subunit 27
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Synonyms
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1500015J03Rik; 2310042P07Rik; AA682045; Crsp8; D2Ertd434e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028139
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InnateDB Gene
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IDBG-153778 (Med27)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0003713
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transcription coactivator activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916225
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InterPro |
IPR021627
Mediator complex, subunit Med27
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PFAM |
PF11571
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DB40
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PhosphoSite |
PhosphoSite-Q9DB40
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TrEMBL |
E0CZG8
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UniProt Splice Variant |
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Entrez Gene |
68975
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UniGene |
Mm.330109
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RefSeq |
NP_081172
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MGI ID |
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MGI Symbol |
Med27
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OMIM |
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CCDS |
CCDS15853
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HPRD |
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IMGT |
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EMBL |
AK005251
AK009764
AK147181
AL772213
AL929437
BC016537
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GenPept |
AAH16537
BAB23906
BAB26488
BAE27743
CAM13399
CAM26819
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