InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc25a4

Summary

InnateDB Protein

IDBP-153789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a4

Protein Name

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Synonyms

Ant1; AU019225;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034049

InnateDB Gene

IDBG-153787 (Slc25a4)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0055085	transmembrane transport
GO:0060546	negative regulation of necroptotic process
GO:0060547	negative regulation of necrotic cell death

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1353495

InterPro

IPR002030 Mitochondrial brown fat uncoupling protein
IPR002067 Mitochondrial carrier protein
IPR002113 Adenine nucleotide translocator 1
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00784
PR00926
PR00927

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48962