Version 5.4
Mus musculus Protein: Higd2a
Summary
InnateDB Protein IDBP-153824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Higd2a
Protein Name HIG1 domain family, member 2A
Synonyms 2010110M21Rik; AA690237;
Species Mus musculus
Ensembl Protein ENSMUSP00000026986
InnateDB Gene IDBG-153822 (Higd2a)
Protein Structure
UniProt Annotation
Function Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion membrane {ECO:0000255PROSITE- ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00836}. Mitochondrion inner membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0055114 oxidation-reduction process
GO:0097250 mitochondrial respiratory chain supercomplex assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914294
InterPro IPR007667 Hypoxia induced protein, domain
PFAM PF04588
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQJ1
PhosphoSite PhosphoSite-Q9CQJ1
TrEMBL
UniProt Splice Variant
Entrez Gene 67044
UniGene
RefSeq NP_080209
MGI ID
MGI Symbol Higd2a
OMIM
CCDS CCDS26532
HPRD
IMGT
EMBL AK005269 AK008387 BC021471
GenPept AAH21471 BAB23921 BAB25641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca