InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo45

Summary

InnateDB Protein

IDBP-153879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo45

Protein Name

F-box protein 45

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040168

InnateDB Gene

IDBG-153877 (Fbxo45)

Protein Structure

UniProt Annotation

Function

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed speciffically in the central nervous system, including cerebellum, medulla oblongata, olfactory bulb, hipocampus, cortex and brain stem. {ECO:0000269PubMed:19398581, ECO:0000269PubMed:19996097}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021800	cerebral cortex tangential migration
GO:0021957	corticospinal tract morphogenesis
GO:0021960	anterior commissure morphogenesis
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0060384	innervation
GO:0060386	synapse assembly involved in innervation

Cellular Component

GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2447775

InterPro

IPR001810 F-box domain
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF00646
PF12937
PF13013
PF00622

PRINTS

PIRSF

SMART

SM00256
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K3B1