Version 5.4
Mus musculus Protein: Tmem17
Summary
InnateDB Protein IDBP-153956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem17
Protein Name transmembrane protein 17
Synonyms AI503894; AW049890;
Species Mus musculus
Ensembl Protein ENSMUSP00000051414
InnateDB Gene IDBG-153954 (Tmem17)
Protein Structure
UniProt Annotation
Function Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269PubMed:22179047}.
Subcellular Localization Cell projection, cilium membrane {ECO:0000269PubMed:22179047}; Multi-pass membrane protein {ECO:0000269PubMed:22179047}. Note=Localizes to the transition zone of primary cilia.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007224 smoothened signaling pathway
GO:0042384 cilium assembly
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035869 ciliary transition zone
GO:0036038 TCTN-B9D complex
GO:0060170 ciliary membrane
Protein Structure and Domains
PDB ID MGI:2144205
InterPro IPR019184 Uncharacterised protein family, transmembrane-17
PFAM PF09799
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0U3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 103765
UniGene
RefSeq NP_705824
MGI ID
MGI Symbol Tmem17
OMIM
CCDS CCDS24470
HPRD
IMGT
EMBL AL731818 BC030386
GenPept AAH30386 CAI25582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca