InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wfikkn1

Summary

InnateDB Protein

IDBP-153981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wfikkn1

Protein Name

WAP, FS, Ig, KU, and NTR-containing protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093141

InnateDB Gene

IDBG-153979 (Wfikkn1)

Protein Structure

UniProt Annotation

Function

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001501	skeletal system development
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity
GO:0032091	negative regulation of protein binding
GO:0043392	negative regulation of DNA binding
GO:0048747	muscle fiber development
GO:0060021	palate development

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:2670967

InterPro

IPR001134 Netrin domain
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008197 Whey acidic protein-type 4-disulphide core
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR018933 Netrin module, non-TIMP type

PFAM