Version 5.4
Mus musculus Protein: Letm1
Summary
InnateDB Protein IDBP-154062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Letm1
Protein Name leucine zipper-EF-hand containing transmembrane protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000005431
InnateDB Gene IDBG-154060 (Letm1)
Protein Structure
UniProt Annotation
Function Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0042407 cristae formation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1932557
InterPro IPR011685 LETM1-like
PFAM PF07766
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2I0
PhosphoSite PhosphoSite-Q9Z2I0
TrEMBL
UniProt Splice Variant
Entrez Gene 56384
UniGene Mm.426453
RefSeq NP_062668
MGI ID
MGI Symbol Letm1
OMIM
CCDS CCDS19207
HPRD
IMGT
EMBL AB041582 AF061026 BC023862 BC046326 BC055865 BC061115
GenPept AAD13139 AAH23862 AAH46326 AAH55865 AAH61115 BAB93544

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca