InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp8b1

Summary

InnateDB Protein

IDBP-154068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp8b1

Protein Name

ATPase, class I, type 8B, member 1

Synonyms

AI451886; FIC1; Ic;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025482

InnateDB Gene

IDBG-154066 (Atp8b1)

Protein Structure

UniProt Annotation

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. Plays a role in bile salt homeostasis. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. Required for the preservation of cochlear hair cells in the inner ear. According PubMed:20852622 is proposed to act as cardiolipin transporter during inflammatory injury; the function is questioned by PubMed:21475228. {ECO:0000269PubMed:14976163, ECO:0000269PubMed:19478059, ECO:0000269PubMed:20852622, ECO:0000269PubMed:21475228, ECO:0000269PubMed:21820390}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20852622}; Multi-pass membrane protein {ECO:0000269PubMed:20852622}. Apical cell membrane {ECO:0000250}. Cell projection, stereocilium {ECO:0000269PubMed:20852622}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B.

Disease Associations

Tissue Specificity

Hepatocytes, bile duct, intestinal epithelial cells (cholangiocytes and ileocytes), and pancreatic acinar cells. {ECO:0000269PubMed:14976163}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:1901612	cardiolipin binding

Biological Process

GO:0006812	cation transport
GO:0006855	drug transmembrane transport
GO:0007605	sensory perception of sound
GO:0008206	bile acid metabolic process
GO:0015914	phospholipid transport
GO:0021650	vestibulocochlear nerve formation
GO:0032534	regulation of microvillus assembly
GO:0045332	phospholipid translocation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060119	inner ear receptor cell development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0032420	stereocilium

Protein Structure and Domains

PDB ID

MGI:1859665

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q148W0