Version 5.4
Mus musculus Protein: Slc10a1
Summary
InnateDB Protein IDBP-154113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc10a1
Protein Name solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms Ntcp;
Species Mus musculus
Ensembl Protein ENSMUSP00000093229
InnateDB Gene IDBG-154111 (Slc10a1)
Protein Structure
UniProt Annotation
Function The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008508 bile acid:sodium symporter activity
GO:0015125 bile acid transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID MGI:97379
InterPro IPR002657 Bile acid:sodium symporter
IPR004710 Bile acid transporter
PFAM PF01758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08705
PhosphoSite PhosphoSite-O08705
TrEMBL
UniProt Splice Variant
Entrez Gene 20493
UniGene Mm.486361
RefSeq NP_035517
MGI ID
MGI Symbol Slc10a1
OMIM
CCDS CCDS49101
HPRD
IMGT
EMBL AB003303 BC021154 BC094023 U95131
GenPept AAB81023 AAH21154 AAH94023 BAA19846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca