InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gch1

Summary

InnateDB Protein

IDBP-154180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gch1

Protein Name

GTP cyclohydrolase 1

Synonyms

Gch; GTP-CH; GTPCH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087405

InnateDB Gene

IDBG-154178 (Gch1)

Protein Structure

UniProt Annotation

Function

May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003934	GTP cyclohydrolase I activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008270	zinc ion binding
GO:0030742	GTP-dependent protein binding
GO:0042803	protein homodimerization activity
GO:0050662	coenzyme binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006461	protein complex assembly
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0014916	regulation of lung blood pressure
GO:0032496	response to lipopolysaccharide
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0035998	7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311	vasodilation
GO:0042416	dopamine biosynthetic process
GO:0042559	pteridine-containing compound biosynthetic process
GO:0045776	negative regulation of blood pressure
GO:0046654	tetrahydrofolate biosynthetic process
GO:0048265	response to pain
GO:0050884	neuromuscular process controlling posture
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051066	dihydrobiopterin metabolic process
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization