Version 5.4
Mus musculus Protein: Osta
Summary
InnateDB Protein IDBP-154241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osta
Protein Name organic solute transporter alpha
Synonyms AV001382; AW261577; D630035O19Rik; Osta; OSTalpha;
Species Mus musculus
Ensembl Protein ENSMUSP00000046286
InnateDB Gene IDBG-154239 (Osta)
Protein Structure
UniProt Annotation
Function Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. {ECO:0000269PubMed:15563450, ECO:0000269PubMed:16317684, ECO:0000269PubMed:18292224, ECO:0000269PubMed:22535958}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B.
Disease Associations
Tissue Specificity Present at high levels in ileum. In ileum, it is restricted to the apical domain on the mature villus enterocytes with little detectable expression in the goblet cells or crypt enterocytes (at protein level). Expressed in kidney but not in heart, brain, liver, spleen, embryo, lung, thymus, ovary nor testis. {ECO:0000269PubMed:15563450, ECO:0000269PubMed:16317684}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006810 transport
GO:0015721 bile acid and bile salt transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2146634
InterPro IPR005178 Organic solute transporter subunit alpha/Transmembrane protein 184
PFAM PF03619
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R000
PhosphoSite PhosphoSite-Q8R000
TrEMBL
UniProt Splice Variant
Entrez Gene 106407
UniGene
RefSeq NP_666044
MGI ID
MGI Symbol Slc51a
OMIM
CCDS CCDS28121
HPRD
IMGT
EMBL AK052725 AK147155 BC024441 BC025912 BC031178
GenPept AAH24441 AAH25912 AAH31178 BAC35116 BAE27722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca