Version 5.4
Mus musculus Protein: Anapc16
Summary
InnateDB Protein IDBP-154299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anapc16
Protein Name anaphase promoting complex subunit 16
Synonyms 2310005G07Rik; APC16; D10Ertd641e;
Species Mus musculus
Ensembl Protein ENSMUSP00000020307
InnateDB Gene IDBG-154297 (Anapc16)
Protein Structure
UniProt Annotation
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:20360068}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20360068}. Nucleus {ECO:0000269PubMed:20360068}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1289325
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL S4R2B6
UniProt Splice Variant
Entrez Gene 52717
UniGene
RefSeq
MGI ID
MGI Symbol Anapc16
OMIM
CCDS
HPRD
IMGT
EMBL AC154040 AK009172 AK012280 AK088376 BC025117 CH466553
GenPept AAH25117 BAB26121 BAB28138 BAC40315 EDL32187 EDL32188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca