InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apba1

Summary

InnateDB Protein

IDBP-154302.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apba1

Protein Name

amyloid beta (A4) precursor protein binding, family A, member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025830

InnateDB Gene

IDBG-154300 (Apba1)

Protein Structure

UniProt Annotation

Function

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-AAP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.Isoform 3: Golgi apparatus.

Disease Associations

Tissue Specificity

Isoform 3 is expressed in brain. {ECO:0000269PubMed:23737971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0010468	regulation of gene expression
GO:0014047	glutamate secretion
GO:0014051	gamma-aminobutyric acid secretion
GO:0035264	multicellular organism growth

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm