InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk17b

Summary

InnateDB Protein

IDBP-154329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk17b

Protein Name

serine/threonine kinase 17b (apoptosis-inducing)

Synonyms

3110009A03Rik; AI120141; Drak2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027263

InnateDB Gene

IDBG-154327 (Stk17b)

Protein Structure

UniProt Annotation

Function

Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Colocalizes with STK17B at the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0012501	programmed cell death
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:2000271	positive regulation of fibroblast apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2138162

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt