InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs4

Summary

InnateDB Protein

IDBP-154335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs4

Protein Name

suppressor of cytokine signaling 4

Synonyms

3110032M18Rik; A730004F22Rik; AI427843; AU015727; AU015859; Socs7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066031

InnateDB Gene

IDBG-154333 (Socs4)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth