Mus musculus Protein: Hecw2 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-154420.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Hecw2 | ||||||||
Protein Name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000084942 | ||||||||
InnateDB Gene | IDBG-154418 (Hecw2) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:2685817 | ||||||||
InterPro |
IPR000008
C2 domain IPR000569 HECT IPR001202 WW domain |
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PFAM |
PF00168
PF00632 PF00397 |
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PRINTS |
PR00360
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PIRSF | |||||||||
SMART |
SM00239
SM00119 SM00456 |
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q6I6G8 | ||||||||
PhosphoSite | PhosphoSite-Q6I6G8 | ||||||||
TrEMBL | Q8BQD5 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 329152 | ||||||||
UniGene | Mm.447527 | ||||||||
RefSeq | NP_001001883 | ||||||||
MGI ID | |||||||||
MGI Symbol | Hecw2 | ||||||||
OMIM | |||||||||
CCDS | CCDS14956 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AB182244 AK042922 AK050978 AK129325 BC107219 BC134353 CH466548 | ||||||||
GenPept | AAI07220 AAI34354 BAC31406 BAC34482 BAC98135 BAD23960 EDL00005 | ||||||||