InnateDB Protein
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IDBP-154422.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hecw2
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Protein Name
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HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000095348
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InnateDB Gene
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IDBG-154418 (Hecw2)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0042787
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protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
MGI:2685817
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InterPro |
IPR000008
C2 domain
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PFAM |
PF00168
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
Q6I6G8
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PhosphoSite |
PhosphoSite-Q6I6G8
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TrEMBL |
A3KPB7
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UniProt Splice Variant |
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Entrez Gene |
329152
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UniGene |
Mm.447527
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RefSeq |
NP_766243
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MGI ID |
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MGI Symbol |
Hecw2
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OMIM |
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CCDS |
CCDS14957
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HPRD |
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IMGT |
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EMBL |
AB182244
AK042922
AK129325
BC107219
BC134353
CH466548
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GenPept |
AAI07220
AAI34354
BAC31406
BAC98135
BAD23960
EDL00005
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