Version 5.4
Mus musculus Protein: Enpp6
Summary
InnateDB Protein IDBP-154437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Enpp6
Protein Name ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000044608
InnateDB Gene IDBG-154435 (Enpp6)
Protein Structure
UniProt Annotation
Function Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in kidney with a lesser expression in brain and heart. {ECO:0000269PubMed:15788404}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0047390 glycerophosphocholine cholinephosphodiesterase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0019695 choline metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2445171
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF01663
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGN3
PhosphoSite PhosphoSite-Q8BGN3
TrEMBL
UniProt Splice Variant
Entrez Gene 320981
UniGene Mm.211429
RefSeq NP_796278
MGI ID
MGI Symbol Enpp6
OMIM
CCDS CCDS40335
HPRD
IMGT
EMBL AK046797 AK046881 BC096376
GenPept AAH96376 BAC32873 BAC32906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca