InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc5a

Summary

InnateDB Protein

IDBP-154480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc5a

Protein Name

unc-5 homolog A (C. elegans)

Synonyms

mKIAA1976; Unc5h1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026994

InnateDB Gene

IDBG-154478 (Unc5a)

Protein Structure

UniProt Annotation

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones. {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to central nervous system. {ECO:0000269PubMed:12351186}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0033564	anterior/posterior axon guidance

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:894682

InterPro

IPR000488 Death domain
IPR000884 Thrombospondin, type 1 repeat
IPR000906 ZU5
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011029 Death-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF00531
PF00090
PF00791
PF07679

PRINTS

PIRSF

SMART

SM00005
SM00209
SM00218
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K1S4