Version 5.4
Mus musculus Protein: Whsc2
Summary
InnateDB Protein IDBP-154558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Whsc2
Protein Name Wolf-Hirschhorn syndrome candidate 2 (human)
Synonyms Whsc2; Whsc2h;
Species Mus musculus
Ensembl Protein ENSMUSP00000030993
InnateDB Gene IDBG-154556 (Whsc2)
Protein Structure
UniProt Annotation
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in brain, heart, spleen, lung, liver, muscle, kidney and testis. Already expressed in 7 dpc embryos. {ECO:0000269PubMed:10409432}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032021 NELF complex
Protein Structure and Domains
PDB ID MGI:1346098
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG30
PhosphoSite PhosphoSite-Q8BG30
TrEMBL
UniProt Splice Variant
Entrez Gene 24116
UniGene Mm.423376
RefSeq NP_036044
MGI ID
MGI Symbol Nelfa
OMIM
CCDS CCDS19208
HPRD
IMGT
EMBL AF101435 AK012673 AK078760 AK088384 BC018423 BC038003
GenPept AAC72983 AAH18423 AAH38003 BAB28399 BAC37379 BAC40319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca